中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (7): 1033-1038.doi: 10.3969/j.issn.2095-4344.2014.07.009

• 组织构建与生物力学 tissue construction and biomechanics • 上一篇    下一篇

基于“心肌桥-冠状动脉”模拟装置的切应力研究

丁  皓1,2,兰海莲1,尚  昆1,2   

  1. 1上海理工大学医疗器械与食品学院,上海市  200093
    2上海医疗器械高等专科学校,上海市  200093
  • 修回日期:2013-12-07 出版日期:2014-02-12 发布日期:2014-02-12
  • 作者简介:丁皓,男,1964年生,上海市人,汉族,博士,副教授,主要从事生物医学与康复工程的研究。
  • 基金资助:

    上海市教育委员会科研创新项目(13YZ148);上海理工大学国家级项目培育基金项目(13XGM08)

A research on the shear stress for “myocardial bridge-coronary artery” analog device

Ding Hao1, 2, Lan Hai-lian1, Shang Kun1, 2   

  1. 1School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
    2Shanghai Medical Instrumentation College, Shanghai 200093, China
  • Revised:2013-12-07 Online:2014-02-12 Published:2014-02-12
  • About author:Ding Hao, M.D., Associate professor, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Shanghai Medical Instrumentation College, Shanghai 200093, China
  • Supported by:

    the Scientific Research Innovation Project of Shanghai Municipal Education Committee, No.13YZ148; the National-Level Cultivation Project of University of Shanghai for Science and Technology, No. 13XGM08

摘要:

背景:在动脉粥样硬化的研究领域,由于人体血液动力学环境的复杂性,动脉粥样硬化与血流动力学壁面切应力的相关性难以作出确切定论。
目的:模拟心肌桥-冠状动脉装置,分析壁冠状动脉血液动力学参数的变化特征与动脉粥样硬化间的关系。
方法:采用心肌桥-冠状动脉模拟装置进行体外模拟实验,保持系统温度、平均流量和心率等相关参数不变,调节心肌桥对壁冠状动脉的压迫程度,观察并记录壁冠状动脉近端和远端切应力平均值和震荡值的变化情况。
结果与结论:0%压迫时,壁冠状动脉近端和远端的切应力平均值和震荡值差异均不显著;50%压迫时,近端切应力震荡值明显大于远端;80%压迫时,远端切应力平均值大于近端,近端切应力震荡值大于远端。随压迫程度的增加,切应力的平均值远端高于近端,而震荡值近端高于远端。提示壁冠状动脉近端切应力震荡值的升高是导致其动脉粥样硬化发生的重要因素。



中国组织工程研究
杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程


全文链接:

关键词: 组织构建, 组织工程, 心肌桥, 冠状动脉, 动脉粥样硬化, 切应力, 血液动力学, 内皮细胞

Abstract:

BACKGROUND: It is difficult to make an exact conclusion about the correlation between atherosclerosis and hemodynamic wall shear stress because of the complexity of the hemodynamic environment in the field of atherosclerosis research.
OBJECTIVE: To analyze the relationship between characteristics of mural coronary artery hemodynamics parameters and atherosclerosis through myocardial bridge-coronary artery analog device.
METHODS: Myocardial bridge-coronary artery analog device was used to simulate experiments in vitro. In the condition of keeping any related parameters unchanged, such as system temperature, the average flow rate and heart rate, we observed and recorded the changes of proximal and distal mean value and oscillatory value of shear stress of mural coronary artery by regulating the oppression level of myocardial bridge to mural coronary artery.
RESULTS AND CONCLUSION: Under 0% oppression, there was no significant difference in distal and proximal mean value and oscillatory value of shear stress of mural coronary artery. Under 50% oppression, the proximal oscillatory value of shear stress was significantly larger than that in the distal end. Under 80% oppression, mean shear stress in the distal end was larger than that in the proximal end. Oscillatory value of shear stress in the proximal end was larger than that in the distal end. With increased oppression, the mean shear stress in the distal end was higher than that in the proximal end, but oscillatory value in the proximal end was higher than that in the distal end. These results indicated that the increase of the oscillatory value of the proximal shear stress of mural coronary artery is an important factor for the occurrence of atherosclerosis.



中国组织工程研究
杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程


全文链接:

Key words: myocardial bridge, coronary vessels, coronary artery disease, hemodynamics

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